Some common heterocyclic compound, 114897-91-5, name is 2-(4-Bromo-2-fluorophenyl)acetonitrile, molecular formula is C8H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(4-Bromo-2-fluorophenyl)acetonitrile
To a solution of Mel (3.2 mL, 49.3 mmol) in anhydrous DMF (82 mL) at 0 C was added NaH (60%, 2.0 g), followed by (4-bromo-2-fluorophenyl) acetonitrile (3.5 g, 16.4 mmol). The mixture was slowly warmed up to room temperature and stirred for 3 hours. The reaction was quenched by the addition of saturated NH4CI and extracted with EtOAc (3 x 150 mL). The combined organic extracts were washed with brine, dried with NA2SO4 and evaporated to dryness. The mixture was purified by flash column chromatography (0-20 % EtOAc in hexanes) to give the product (3. 0 g, 77% yield).’H NMR (300 MHz, CDC13) B : 1.78 (s, 6 H), 7.26-7. 42 (m, 3 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 114897-91-5, its application will become more common.
Reference:
Patent; PFIZER INC.; WO2004/74270; (2004); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts