Related Products of 127667-01-0, These common heterocyclic compound, 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
11 g of 2-fluoro-5-methoxybenzonitrile was added to a mixed solvent of 200 ml of methanol and 100 ml of water. Further, 9 g of hydroxylamine hydrochloride and 12 g of anhydrous sodium acetate were added, and the reaction was stirred under reflux for 12 hours. Add water and ethyl acetate, extract the liquid, collect the organic phase, dry, concentrate, The residue was separated on a silica gel column to obtain 9 g of 2-fluoro-N’-hydroxy-5-methoxybenzidine.
The synthetic route of 127667-01-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Deng Zeping; (6 pag.)CN108129415; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts