Some scientific research about 1885-38-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Cinnamonitrile, and friends who are interested can also refer to it.

Synthetic Route of 1885-38-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1885-38-7 name is (E)-Cinnamonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of cheliensisin A (548 mg, 2 mmol) in PhCN (10 mL) at -20 C, a solution of BF3·OEt2 (668 muL, 2 mmol) in PhCN (5 mL) was added over 15 min. The reaction completed in 1 h with TLC judgment. A saturated aqueous NaHCO3 solution (12 mL) was then added to quench the reaction. The mixture was extracted with dichloromethane (100 mL × 3). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was subjected to flash chromatography on silica gel (ethyl acetate/petrol ether = 1:3) to give compounds 2a and 2b as white foams in 34% (257 mg) and 53% (403 mg), respectively.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Cinnamonitrile, and friends who are interested can also refer to it.

Reference:
Article; Deng, Xu; Su, Jia; Zhao, Yu; Peng, Li-Yan; Li, Yan; Yao, Zhu-Jun; Zhao, Qin-Shi; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4238 – 4244;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts