In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22364-68-7 as follows. HPLC of Formula: C9H9N
1-(2-Methylphenyl)acetonitrile (610 mg) was dissolved in dimethyl sulfoxide (6.1 ml), added with sodium hydride (60% in oil, 409 mg) and stirred at room temperature for 30 minutes. This reaction mixture was added with a solution of bis(2-chloroethyl)benzylamine (1.090 g) obtained above dissolved in dimethyl sulfoxide (6.1 ml) and further stirred at 75 C. for 2.5 hours. The reaction mixture was added with water (50 ml) and extracted twice with ether (50 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: hexane:ethyl acetate=6:1) to obtain 1.077 g of the title compound. Yield: 80%. 1H-NMR (CDCl3); delta (ppm) 2.07 (2H, td, J=12Hz, 3Hz), 2.32 (2H, dd, J=12Hz, 3Hz), 2.59 (2H, t, J=12Hz), 2.64 (3H, s), 3.01 (2H, d, J=12Hz), 3.61 (2H, s), 7.20-7.40 (9H, m) MS (TSP); m/z 291 (MH+)
According to the analysis of related databases, 22364-68-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Tsushima, Masaki; Tadauchi, Kaori; Asai, Kenji; Miike, Naoko; Kudo, Toshiaki; US2003/176693; (2003); A1;,
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