Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, A new synthetic method of this compound is introduced below., SDS of cas: 654-70-6
In a 500 mL four necked round bottomed flask equipped with nitrogen atmosphere facility, mechanical stirrer, thermometer and an addition funnel, (15 g) 4-amino-2-(trifluoromethyl)benzonitrile, 150 mL water and 75 mL dichloromethane were added at 20-30 C. The reaction mixture was stirred for 15 min and 9 mL thiophosgene was added. The reaction mixture was stirred for 4 hours. After completion of the reaction, the layers were separated and the organic layer was concentrated completely U/V at 40 C. 105 mL, hexane was added to the concentrated reaction mass and cooled 0 to 5 C. The compound was filtered, washed with hexane and dried to obtain 20 g titled compound with 98% purity by HPLC.
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cadila Healthcare Limited; Dwivedi, Shri Prakash Dhar; Singh, Kumar Kamlesh; Charan, Ganpat Dan Shimbhu; (16 pag.)US2017/158643; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts