14533-86-9, name is Methyl (E)-2-Cyano-3-phenylacrylate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl (E)-2-Cyano-3-phenylacrylate
General procedure: A solution of 5,5-dimethylcyclohexane-1,2-dione (13, 35.3 mg, 0.10 mmol) and catalyst 7 (5.94 mg. 0.0010 mmol, 10 mol %) in toluene (1.0 mL) was stirred at 0 C for 15 minutes. To this solution was added alkyl (E)-2-cyano-3-phenylacrylate (14, 0.12 mmol) and the mixture was stirred at 0 C until the reaction was completed (TLC monitoring). The solvent was then removed under reduced pressure and the residue was purified by silica gel chromatography to afford the product 15.
The synthetic route of 14533-86-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ramireddy, Naresh; Abbaraju, Santhi; Zhao, Cong-Gui; Tetrahedron Letters; vol. 52; 50; (2011); p. 6792 – 6795;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts