New downstream synthetic route of

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-82-6, name is 4-Amino-2-bromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5BrN2

40 mg CuCI were dissolved in 10 m I water and cooled in an ice bath to 00C. 1.6 ml thionylchloride were added dropwise. The reaction solution was allowed to warm to roomtemperature overnight.1.O g 4-Amino-2-bromo-benzonitrile were suspended in 12 ml hydrochlorc acid and 45 ml water and warmed to 960C until all 4-Amino-2-bromo-benzonitrile were dissolved. The solution was cooled to -5C and 380 mg NaNO2 dissolved in 10 ml water were added. Then the thionlychloride solution was cooled to -2C and added dropwise. The 3-Bromo-4-cyano-benzenesulfonyl chloride precipitated and was collected by filtration and washed with ice cooled water and dried under vacuo to obtain 956 mg 3-Bromo-4- cyano-benzenesulfonyl chloride as a solid. This material was used without further purification. C7H3BrCINO2S (280.53).

According to the analysis of related databases, 53312-82-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS; WO2009/149820; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts