Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 916792-13-7, name is 4-Bromo-2-fluoro-5-methylbenzonitrile, A new synthetic method of this compound is introduced below., Formula: C8H5BrFN
A mixture of 4-bromo-2-fluoro-5- methylbenzonitrile (4.0 g, 18.7 mmol), potassium vinyltrifluoroborate (2.8 g, 20.6 mmol) and Pd(dppf)2Cl2 (0.4 g, 0.6 mmol) in 40 mL of EtOH and 13 mL of TEA was refluxed under Ar for 4 hours. The reaction mixture was concentrated, and the residue was purified by column chromatography (petrol ether : EtOAc = 10 : 1) to afford the title compound as a yellow solid
The synthetic route of 916792-13-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; PIO, Barbara; CHOBANIAN, Harry, R.; SHI, Zhi-Cai; DONG, Shuzhi; GUO, Yan; WALSH, Shawn, P.; GUO, Zhiqiang; FERGUSON, Ronald, D.; CATO, Brian; (114 pag.)WO2016/60941; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts