In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876-31-3 as follows. name: 4-(Cyanomethyl)benzonitrile
10-Ethylphenothiazine-3-carbaldehyde (10 mmol, 2.55 g) and 4-(cyanomethyl)benzonitrile (10 mmol, 1.42 g)Dissolve in ethanol (20 mL) and THF (10 mL), then add ammonium acetate (10 mmol, 0.77 g) to the reaction system.The mixture was stirred at room temperature for 12 hours. After the reaction and filtration are complete, the crude product is purified by column chromatography.Ethyl acetate:n-hexane=1:4 was used as an eluent. 4-(1-cyano-2-(10-ethyl-phenothiazine-3-yl)vinyl)benzonitrile (3.15 g, yield 83%) was obtained as a red powdery solid.
According to the analysis of related databases, 876-31-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Woman Child Medical Treatment Center; Gong Sitang; Xu Wanfu; Geng Lanlan; Yang Min; Chen Peiyu; Xu Chaohui; He Liying; Chen Huan; Ye Liping; Wang Hongli; Li Huiwen; Xie Jing; Zhao Junhong; Xiong Liya; Liang Cuiping; Cheng Yang; Cao Meiwan; (12 pag.)CN107501207; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts