Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63069-50-1, name is 4-Amino-3-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Amino-3-fluorobenzonitrile
General procedure: The compound 4-((2-chlorothieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile (1.0 mmol) was weighed.Fluorine or trifluoromethyl substituted p-cyanoaniline (1.2 mmol), palladium acetate (0.02 g, 0.1 mmol),4,5-bis (diphenylphosphino) -9,9-dimethyl xanthene (0.06g, 0.1mmol) and cesium carbonate (0.65g, 2mmol) was added in 15mL of dioxane,The mixture was heated to reflux under nitrogen atmosphere for 12 hours.After the reaction was cooled to room temperature, it was filtered over Celite and evaporated to dryness.Then, the mixture was dissolved in dichloromethane, and brine (3×5 mL) was evaporated.The target compound was isolated by flash column chromatography, and then recrystallized from ethyl acetate- petroleum ether system to give the objective compound A1-A20.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63069-50-1.
Reference:
Patent; Shandong University; Liu Xinyong; Kang Dongwei; Zhan Peng; (25 pag.)CN108440559; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts