These common heterocyclic compound, 54454-12-5, name is 3-Chloro-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Chloro-2-methylbenzonitrile
Step A Preparation of 2-chloro-6-cyanobenzyl bromide To a refluxing solution of 3-chloro-2-methylbenzonitrile (2.0 g,13.2 mmol) in 20 mL of CCl4 was added 2.6 g (14.4 mmol, 1.1 eq) of N-bromosuccinimide and 0.2 g of AIBN. The solution was refluxed for 3 hours and then cooled, diluted with 500 mL of CH2 Cl2 and washed with 200 mL of H2 O and 200 mL of brine. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. The resultant oil was flash chromatographed with 5:1 hexane/ethyl acetate to yield the titled compound (1.4 g, 46%) as a yellow oil. FAB-MS: m/e=230 (M+1) 1 H NMR (400 MHz, CDCl3, ppm) d 7.63 (dd, 1H); 7.58 (dd, 1H); 7.37 (t, 1H); 4.74 (s, 2H).
The synthetic route of 3-Chloro-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck & Co., Inc.; US5175164; (1992); A;,
Nitrile – Wikipedia,
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