Application of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 136a (477 mg, 4.38 mmol) in MeOH (5 mL) was added N2H4.H20 (80%) (5 mL). The reaction mixture was heated at 75C for 15 h. MeOH was removed under reduced pressure. The residue was extracted with CH2CI2 (2 X 8 mL ), dried over Na2S04, and concentrated. The residue was purified by flash column eluting with 100: 1 CH2CI2/ MeOH to afford 136b as a yellow oil (37%, for two steps). LCMS: (M+H)+ 124.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GILEAD CONNECTICUT, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., M.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KRISHNAMOORTHY, Ravi; KROPF, Jeffrey, E.; LEE, Seung H.; MITCHELL, Scott A.; ORTWINE, Daniel; SCHMITT, Aaron, C.; WANG, Xiaojing; XU, Jianjun; YOUNG, Wendy; ZHANG, Honglu; ZHAO, Zhongdong; ZHICHKIN, Pavel E.; WO2011/140488; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts