Application of 874-89-5, A common heterocyclic compound, 874-89-5, name is 4-(Hydroxymethyl)benzonitrile, molecular formula is C8H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
8B. N-Hydroxy-4-hydroxymethyl-benzamidine Hydroxylamine hydrochloride (5.17 g, 75.0 mmol) and sodium bicarbonate (12.6 g, 150 mmol) were added to a solution of 4-hydroxymethyl-benzonitrile (5.0 g, 37.5 mmol) and methanol (65.0 mL). The reaction was heated to reflux for 12 hours. The reaction mixture was cooled to room temperature and the resulting slurry was filtered. The filtrate was concentrated in vacuo to give of the title compound (6.0 g, 48% yield) as an oily solid. 1H NMR (400 MHz, CD3OD) 4.60 (s, 2H), 7.36 (d, 2H), 7.59 (d, 2H).
The synthetic route of 874-89-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc; US2007/270438; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts