Synthetic Route of 654-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Lithium bis (trimethylsilyl) amide (LHMDS) (5 eq.) was added to a solution of 4-cyano-3-trifluoromethyl aniline (1.6 eq.) in dry THF (1 mL x mmol aniline) at -5C. After stirring for 45 min., hexamethylphosphoric triamide (HMPA) (20% of the previously added, THF) . After 5 min at -5C a solution of (R) -XVIII-5 in THF (1.5 mL x mmol of (.R)-XVIII-S) was added drop wise. After 30 min at 00C, the reaction mixture was allowed to warm up at the temperature value (25C) and than stirred for additional 6/7 h. The reaction was than quenched with an NH4Cl saturated solution and extracted with ethyl acetate. Silica gel column chromatography or crystallization, afforded the pure compound.(R) -XXIV-I: 1H NMR (400 MHz, CDCl3) : bs, IH, NH) , 7.69 (d, J= 8.8Hz, 2H, 7.53-7.48 (m, 3H, ArH) , 7.39-7.26 (m, H) , 6.84 (t, J= 8.2Hz, 2H, ArH) , 3.90(d, J= 14.4Hz, IH, CH2) , 3.78 (bs, IH, OH) , 3.26 (d, J= 13.6Hz, IH, CH2) , 3.07 (d, J= 14.4Hz, IH, CH2) , 2.95 (d, J= 13.2Hz, IH, CH2)
The synthetic route of 4-Cyano-3-trifluoromethylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CONSIGLIO NAZIONALE DELLE RICERCHE; ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (I.R.S.T.) S.R.L.; VARCHI, Greta; TESEI, Anna; GUERRINI, Andrea; BRIGLIADORI, Giovanni; WO2010/116342; (2010); A2;,
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