Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14618-78-1, name is 4,4-Dimethoxybutanenitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H11NO2
To a solution of diisopropylamine (4.77 mL, 34.1 mmol, 2.2 equiv) in THF (50 mL) at -10Cunder N2 was added 1.5 M n-BuLi in hexanes (22.7 mL, 34.1 mmol, 2.2 equiv). After 30 mm the mixturewas cooled to -78 C and a solution of nitrile (2.0 g, 15.5 mmol, 1.0 equiv) in THF (10 mL) was added.After 1 h iodomethane (2.12 mL, 34.1 mmol, 2.2 equiv) was added. The mixture was slowly warmed to 0C and kept there for 14 h, at which time it was quenched with sat. aq. NH4C1 (40 mL) and extracted withEtOAc (3 x 20 mL). The organics were dried over Na2SO4, filtered and concentrated in vacuo. Theresultant oil was purified by flash chromatography on silica gel (5:1 -3:1 hexanes/EtOAc) to yield theproduct (2.105 g, 87%) as a yellow oil. R1= 0.49 (3:1 hexanes/EtOAc). ?HNMR(400 MHz, CDC13) 3:4.60 (t, 1H, J= 5.6 Hz), 3.37 (s, 6H), 1.83 (d, 2H, J= 4.4 Hz), 1.39 (s, 6H); ?3C NMR (100 MHz, CDC13)3: 124.7, 102.4, 53.3, 43.0, 30.0, 27.5
The synthetic route of 14618-78-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; SALK INSTITUTE FOR BIOLOGICAL STUDIES; PACHE, Lars; CHANDA, Sumit, K.; VAMOS, Mitchell, Dennis; COSFORD, Nicholas David, Peter; TERIETE, Peter; MARLETT, John; DIAZ, Arturo; YOUNG, John, A.T.; WO2015/187998; (2015); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts