Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-(4-Fluorophenyl)-3-oxopropanenitrile
100 mL flask into a commercially available chemicals of p-fluorobenzoylacetonitrile(1) (3.2898 g, 20.16 mmol) was and suspensions put a polyphosphoric acid (20mL). This in acetone (2.4177 g, 41.63 mmol) was added and stirred for 30minutes at 80 to 90 C, and stirred for 30minutes from 140 to 150 C agitated at 30 minutes. Ice is poured into a beaker filled with a reactionliquid (100 ml), sodium carbonate powder is added carefully and neutralizedwith chloroform extracts 4 times, after drying with anhydrous sodium sulfate,distillation, solvent. Residue obtained from the recrystallization and ethylacetate, compd. 2a (2. 2037 g, 10. 84 mmol, 54%) is obtained.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4640-67-9.
Reference:
Patent; SHIONOGI & COMPANY LIMITED; SUZUKI, HIDEYUKI; (33 pag.)JP2016/700; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts