Synthetic Route of 67515-59-7, These common heterocyclic compound, 67515-59-7, name is 4-Fluoro-3-(trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 54 4-(3-formyl-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile; [Show Image] To a solution (20 mL) of 3-hydroxy-2-methoxybenzaldehyde (1.00 g) in dimethyl sulfoxide were added lithium carbonate (743 mg) and 4-fluoro-3-(trifluoromethyl)benzonitrile (1.54 g), and the mixture was stirred at 100C for 4 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and filtered, and the filtrate was concentrated under reduced pressure. The residue was washed with diisopropylether to give the title compound as a pale-yellow solid (yield: 1.50 g, 71%). 1H-NMR (DMSO-d6, 300 MHz):delta3.86 (3H, s), 7.01 (1H, d, J = 8.7 Hz), 7.40 (1H, dd, J = 8.1, 7.1 Hz), 7.62 (1H, dd, J = 8.1, 1.7 Hz), 7.74 (1H, dd, J = 7. 7, 1.7 Hz), 8.07 (1H, dd, J = 8.7, 2.1 Hz), 8.40 (1H, d, J = 2.1 Hz), 10.31 (1H, s).
Statistics shows that 4-Fluoro-3-(trifluoromethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 67515-59-7.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2450352; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts