Simple exploration of

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H6ClN

A mixture of l-methylimidazole (8.21g, 0.10 mmol) and Cl(CH₂)₃CN (12.43g, 0.12 mol)is stirred at 807deg;C for 24 hours. The resulting white solid is washed with diethyl ether (3 x 30 ml). The product is dried in vacuum for 24 hours. Yield: 17.6 g, 95%; M.p. 80C. ESI-MS(CH₃OH): Positive ion: 150 [C,sub>3CNmim], negative ion: 35 [Cl]. 1H NMR (CDCl₃): delta= 8.73 (s, 1H), 7.45 (s, 1H), 7.39 (s, 1H), 4.27 (t, J(H, H) = 6.8 Hz, 2H), 3.82 (s, 3H), 2.50 (t, J(H, H) = 6.8 Hz, 2H), 2.20 (t, J(H, H) = 6.8 Hz, 2H). ₁₃C NMR (CDCl₃): delta = 134.11, 130.49, 120.01, 116.19, 44.01,30.87, 21.21, 9.87. IR (cm-1): 3373, 3244, 3055 (V_C-H aromatic), 3029, 2974, 2949, 2927 (V_C-H aliphatic), 2243 (V_C-N), 1692 (V_C=N). Anal. Calcd for C₈H₁₂ClN₃ (%): C, 51.76, H, 6.51, N, 22.63; Found: C 51.72, H 6.55, N 22.71.

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); WO2005/19185; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts