In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64248-64-2 as follows. name: 2,5-Difluorobenzonitrile
To a solution of 1,1-dimethylethyl (35)-3-pyrrolidinylcarbamate (201 mg, 1.078 mmol) and 2,5-difluorobenzonitrile (150 mg, 1.078 mmol) in DMF (2.0 mL) was added K2CO3 (149 mg, 1.078 mmol). The reaction vial was capped and heated to 100 0C for 5 h. Upon cooling, water (5 mL) and EtOAc (2 mL) were added. The layers were separated, and the aqueous layer was extracted with EtOAc (4 x 2 mL). The combined organic layers were washed with brine (3 x 1 mL) and then concentrated onto Isolute. Purification via flash column chromatography (0-50% EtOAc/hexanes) afforded the title compound (143 mg, 43%). LC-MS m/z 306 (M+H)+, 1.09 min (ret time).
According to the analysis of related databases, 64248-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; BULLION, Ann, Marie; BUSCH-PETERSEN, Jakob; EVANS, Brian; NEIPP, Christopher, E.; MCCLELAND, Brent, W.; NEVINS, Neysa; WALL, Michael, D.; WO2011/25799; (2011); A1;,
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