Related Products of 218632-01-0, The chemical industry reduces the impact on the environment during synthesis 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
The title compound was prepared following the procedure described in step-3, Intermediate80 by using 3-fluoro-4-nitrobenzonitrile (5 g, 30.i mmol), pyridin-3-ylmethanol (5.0 g, 45.i mmol), K2C03 (6.3 g, 45. i mmol) in DMF (30.0 mL) to afford 4.5 g of title compound:_To a solution of 4-iodo-3-(3-(pyridin-3-yloxy)propyl)benzoic acid (500 mg, i .30 mmol) inDMF (iO.0 mL) was added K2C03 (270 mg, i.95 mmol) and the reaction mass was stirred at60C for i h. Then added ethyl bromide (2i3 mg, i.95 mmol) and continued stirring at rt for4-5 h. The reaction mixture was quenched with water and filtered off precipitate to afford 500 mg of title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts