Related Products of 53312-81-5,Some common heterocyclic compound, 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 150 mL four-necked flask with a magnetic stir bar was chargedwith compound 7 (3.24 g, 20 mmol), sodium bicarbonate (3.36 g,40 mmol, 2 equiv) and tetrahydrofuran (70 mL). At 45 C, a solutionof 3-bromo-4-fluoroaniline (4.18 g, 22 mol, 1.1 equiv) in tetrahydrofuran(15 mL)was added to the reaction mixture in 10 min. Thenthe reaction mixture was heat to reflux for another 3 h. Oncompleting of the reaction monitored by TLC, the sodium bicarbonatewas filtered and the filtrate was evaporated in vacuo. Theresidue was dissolved with ethyl acetate (70 mL), washed withwater (40 mL), brine, dried over anhydrous Na2SO4 and concentratedin vacuo. The crude product was slurried in petroleum ether(50 mL) for 1 h and the precipitate was collected by filtration anddried to give the desired product (5.75 g, 91%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-fluorobenzonitrile, its application will become more common.
Reference:
Article; Du, Qianming; Feng, Xi; Wang, Yinuo; Xu, Xi; Zhang, Yan; Qu, Xinliang; Li, Zhiyu; Bian, Jinlei; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Nitrile – Wikipedia,
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