Some common heterocyclic compound, 19295-57-9, name is 3-Hydroxy-2,2-dimethylpropanenitrile, molecular formula is C5H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
To a solution of 9j (0.33g, 1.96mmol) in ethanol (5mL) was added 50% aqueous hydroxylamine solution (0.39g, 5.88mmol), and the reaction mixture was then stirred at room temperature for 1h and evaporated in vacuo. The residue was purified using silica gel column chromatography (methanol/chloroform) to yield 10j (0.23g, 58%) as a colorless oil. 1H NMR (200MHz, CDCl3) delta 1.52-2.09 (m, 7H), 2.87-3.03 (m, 2H), 3.14-3.28 (m, 1H), 3.33-3.46 (m, 1H), 4.35 (br s, 2H), 4.71-4.90 (m, 1H); MS (ESI): m/z 202 [M+H]+, 224 [M+Na]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19295-57-9, its application will become more common.
Reference:
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts