Some common heterocyclic compound, 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, molecular formula is C7H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
Charge 3-ethoxy-4-hydroxy-5-nitrobenzaldehyde 20g (0. 0947mole) of the formula 2 where R= ethyl and N, N-diethylamino cyanoacetamide of the formula (3) 14. 6g, (0.1042), acetic acid 3.13g and piperidine 4.45g along with toluene 200ml and heated to reflux temperature of about 100-115 C with continuous removal of water azeotrophically 15 hours. After the reaction is over the reaction mixture is concentrated to a volume of 20-30ml quenched in to dilute hydrochloric acid and chilled water 200ml and stirred for 60 minutes. The precipitated solid was filtered and dried to get 30g (95%), the HPLC purity is 94% (including isomer) of N, N-DIETHYL – 2-CYANO-3- (-3-ETHOXY-4-HYDROXY-5 NITROPHENYL) ACRYLAMIDE. The product is used as such directly to the. next stage. MR = 110.1- 117. 2 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 26391-06-0, its application will become more common.
Reference:
Patent; SUVEN LIFE SCIENCES LTD; JASTI, Venkat; WO2005/63693; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts