Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks
General procedure: To a solution of 2a (1 equiv.) and amine (1.2 equiv.) in dichloromethane was added triethylamine (2 equiv.) as outlined in reaction Scheme 1. The reaction mixture was cooled to 0C and propylphosphonic acid anhydride (T3P) (2.5 equiv.) was added. The reaction mixture was then warmed to room temperature and stirred for 16 h. After the completion of reaction, the reaction mixture was diluted with dichloromethane and washed successively with saturated sodium bicarbonate solution, water, brine and dried over anhydrous Na2S04. The solvent was then removed under reduced pressure to yield the crude product, which was purified over silica gel using 30%-60% ethyl acetate in pet-ether as eluant to yield the pure IIj in 35 to 40% yields.
The synthetic route of 53312-81-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ST. JUDE CHILDREN’S RESEARCH HOSPITAL; MMV MEDICINES FOR MALARIA VENTURE; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; GUY, Rodney Kiplin; ZHU, Fangyi; CLARK, Julie Anne; GUIGUEMDE, Wendyam Armand; FLOYD, David; KNAPP, Spencer; STEIN, Philip; CASTRO, Steve; WO2013/27196; (2013); A1;,
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