Related Products of 127946-77-4, A common heterocyclic compound, 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, molecular formula is C4H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step H: (1R,2R)-2-(4-(4-bromophenyl)-2-(3,4-difluorophenyl)oxazol-5-yl)-N-(1-cyanocyclopropyl)cyclohexanecarboxamide [0231] To a solution of (1R,2R)-2-(4-(4-bromophenyl)-2-(3,4-difluorophenyl)oxazol-5-yl)cyclohexanecarboxylic acid (72 mg, 0.156 mmol) and HATU (89 mg, 0.389 mmol) in DMF (1 mL) was added 1-cyanocyclopropanaminium chloride (46.2 mg, 0.389 mmol) followed by the addition of Hunig’s base (101 mg, 0.779 mmol) and stirred at 40 C. overnight. The resulting solution was purified directly by reverse phase HPLC (Sunfire C18 30×150 mm column; 40 to 95% MeCN in water. 0.1% TFA modifier for MeCN and water) to give desired product as a white solid (32 mg, 39%).
The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Stachel, Shawn; Paone, Daniel V.; Li, Jing; Nanda, Kausik; US2015/99719; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts