Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-(Trifluoromethyl)benzonitrile
N-Hydroxy-4-trifluoromethylbenzimidamide (47c). 4-Trifluoromethylbenzonitrile 46c (1.37 g, 8.0 mmol) in ethanol (30 mL) was added to hydroxylamine hydrochloride (3.34 g, 48 mmol) and sodium hydrogen carbonate (2.54 g, 24 mmol) in water (30 mL) and the mixture was stirred at 100C for 3 h. The ethanol was evaporated from the cooled mixture and the residue was poured into ice-cold water. The precipitate was collected by filtration, washed (water) and dried to give N-hydroxy-4-trifluoromethyl- benzimidamide 47c (1.60 g, 98%) as a white powder: 1 18-120C (lit.95 128-129C); 1H NMR ((CD3)2SO) delta 6.01 (2 H, br, NH2), 7.79 (2 H, d, J = 8.4 Hz, Ph 2,6-H2), 7.94 (2 H, d, J = 8.4 Hz, Ph 3,5-H2), 9.96 (1 H, s, OH); 13C NMR ((CD3)2SO) delta 124.98 (q, J = 3.1 Hz, 3,5-C2), 125.54 (q, J = 331 Hz, CF3), 126.05 (2,6-C2), 129.17 (1 -C), 137.28 (q, J = 28 Hz, 4-C), 149.76 (C=N); 19F NMR (CDCI3) delta -62.84 (CF3); MS m/z 205.0610 (M + H)+ (C8H8N2OF3 requires 205.0589).
The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF BATH; THREADGILL, Michael David; LLOYD, Matthew David; THOMPSON, Andrew Spencer; NATHUBHAI, Amit; WOOD, Pauline Joy; PAINE, Helen Angharad; KUMPAN, Ekaterina; SUNDERLAND, Peter Thomas; CHUE YEN WOON, Esther; WO2014/87165; (2014); A1;,
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