In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4110-35-4, name is 3,5-Dinitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks
1A. Formula 103 where R1 is Pyridin-3-yl and Y is CN [0094] A solution of 1 equivalent (eq., 25.42 g, 131.6 mmol)) of 1,3 dinitro-5-cyanobenzene in 1.75 M DMF (75 mL),1 eq. 3-hydroxypyridine (12.52g, 131.6 mmol) and 2 eq. potassium carbonate (36.38 g, 263 mmol) was heated to 60Covernight. The reaction mixture was warmed to 95C for an additional 48 hours. The reaction mixture was diluted withEtOAc, washed with H2O, sat. NaHCO3, and brine, dried over Na2SO4 and concentrated in vacuo. Purification bychromatography over silica with 25% EtOAC/Hexane as the eluant afforded 10.04g of the desired compound of Formula103, 3-(pyridin-3-yloxy)-5-cyano-1-nitrobenzene, as a solid (32% yield).
The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cytokinetics, Inc.; MALIK, Fady; TOMASI, Adam, Lewis; FENG, Bainian; KRAYNACK, Erica, Anne; ELIAS, Kathleen; LU, Pu-Ping; SMITH, Whitney, Walter; QIAN, Xiangping; MORGANS, David, J., Jr.; EP1503986; (2015); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts