Synthetic Route of 120351-94-2,Some common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 Synthesis of N-[2-(3-cyanophenoxy)ethyl]-(1R)-10-camphorsulfonamide: The title compound was obtained from 700 mg (4.32 mmol) of 3-(2-aminoethoxy)benzonitrile and 1.08 g (4.32 mmol) of (1R)-(-)-10-camphorsulfonyl chloride in the same manner as that of step 1 in Example 106. Yield: 1.33 g (3.54 mmol) (82 %) MS (ESI, m/z) 377 (MH+)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(2-Aminoethoxy)benzonitrile, its application will become more common.
Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts