Related Products of 1835-65-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1835-65-0 as follows.
EXAMPLE 1 After loading 5.0 g (25.0 mmol) of tetrafluorobenzene-o-dicarbonitrile (melting point: 86° C., Fluorochem Co.) and 4.15 g (25.0 mmol) of potassium iodide into a 100 ml 3-necked flask equipped with a reflux condenser tube, the interior of the flask was exchanged with nitrogen. To this was added 35 ml of dimethylformamide prior to reaction at 140° C. for 3 hours. Upon analysis of the reaction solution by gas chromatography (OV17 column, product of Shimazu Laboratories), 2,2′,5,5′,6,6′-hexafluorobiphenyl-3,3′,4,4′-tetracarbonitrile was found to be produced with a tetrafluorobenzene-o-dicarbonitrile conversion rate of 63percent and 83percent selectivity. After cooling the reaction mixture to room temperature, 150 ml of ethyl acetate was added and the solution was washed with a 3percent aqueous hydrochloric acid solution and then with a 10percent aqueous sodium thiosulfate solution. After distilling off the ethyl acetate, the residue was purified by column chromatography (silica gel/toluene:hexane=7:3) to obtain 2.10 g of 2,2′,5,5′,6,6′-hexafluorobiphenyl-3,3′,4,4′-tetracarbonitrile. The yield was 46percent. The product analysis values were as follows. MS measurement, M+: 362
According to the analysis of related databases, 1835-65-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ube Industries, Ltd.; US5856557; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts