Adding a certain compound to certain chemical reactions, such as: 53312-80-4, name is 4-Amino-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53312-80-4, Formula: C7H5FN2
Preparation 5; 4-Amino-2-fluorobenzoic acid; A mixture of 4-amino-2-fluorobenzonithle (25g, 0.183mmol) and potassium hydroxide (125g, 2.23mol) in water (35OmL) and industrial methylated spirit (5OmL) was heated at reflux for 48 hours. The solvent was evaporated in vacuo and the residue diluted with water (30OmL) and washed with DCM (20OmL). The aqueous phase was acidified to pH = 5.5 with concentrated HCI and the resultant precipitate collected by filtration to yield the title compound as a beige solid (23.94g, 0.154mol).
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Reference:
Patent; PFIZER LIMITED; ICAGEN, INC.; MARKWORTH, Christopher John; MARRON, Brian Edward; SWAIN, Nigel Alan; WO2010/35166; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts