Reference of 26391-06-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Typical procedure for the synthesis of alpha-cyano N-aryl ketene-N,S-acetals 1 (with 1a as an example). To a solution of ethyl cyanoacetate (10.0 mmol) in DMF (30 mL) at room temperature was added potassium carbonate (20.0 mmol) in one portion and the mixture was stirred for 1 h at room temperature. Phenyl isothiocyanate (10.0 mmol) was then added dropwise and the mixture was stirred for 2 h at room temperature. Then 1,2-dibromoethane (10 mmol) was added dropwise. The reaction was quenched with 200 mL of H2O after the mixture was further stirred for 6 h at room temperature. The resulting mixture was extracted with dichloromethane (3×30 mL), and the combined organic phase was washed with water, dried over anhydrous MgSO4, ltered, and evaporated in vacuo. The crude product was puried by silica gel chromatography (petroleum ether: diethyl ether=10:1) to give 1a (2.356 g) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N,N-diethylacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Wu, Chenwei; Huang, Peng; Sun, Zhongqiao; Lin, Mi; Jiang, Yuchun; Tong, Jian; Ge, Chunhua; Tetrahedron; vol. 72; 11; (2016); p. 1461 – 1466;,
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