Adding a certain compound to certain chemical reactions, such as: 10412-93-8, name is N-Benzyl-2-cyanoacetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10412-93-8, Quality Control of N-Benzyl-2-cyanoacetamide
General procedure: To a stirred solution of cyanamide (2, 1.1 mmol) in ethanol (2 mL) were added 2-hydroxybenzaldehyde (1 mmol) and piperidine(catalytic amount), and the resulting mixture was stirred at room temperature for 12 h. The suspension was then filtered to give 4, which was used directly in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Benzyl-2-cyanoacetamide, and friends who are interested can also refer to it.
Reference:
Article; Endo, Satoshi; Hu, Dawei; Suyama, Miho; Matsunaga, Toshiyuki; Sugimoto, Kenji; Matsuya, Yuji; El-Kabbani, Ossama; Kuwata, Kazuo; Hara, Akira; Kitade, Yukio; Toyooka, Naoki; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6378 – 6384;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts