Synthetic Route of 110882-60-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110882-60-5, name is 3-Fluoro-5-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1To a solution of 3-fluoro-5-nitrobenzonitrile (1.0 g, 6.02 mmoL) in TFA (8 mL) was added water (1 mL) and cone, sulfuric acid (2 mL). The reaction mixture was heated to 70 C and stirred for 24 h. Then the reaction mixture was cooled to 0 C and liquid ammonia solution was added. The solidified solid was filtered through Celite (diatomaceous earth) and washed with water to obtain 3-fluoro-5-nitrobenzamide (0.400 g, 36%>) as an off white solid. Observed mass (M-l): 183.02.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-5-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts