Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 874-97-5, name is 3-Cyanobenzyl alcohol, A new synthetic method of this compound is introduced below., name: 3-Cyanobenzyl alcohol
To an ice-cold solution of 3-hydroxymethyl benzonitrile (4.95 g, 37 mmol) in CH2C12 (47 mL) was added imidazole (5.1 g, 74 mmol), DMAP (0.45 g, 3.7 mmol), and TBSC1 (6. 2 g, 41 mmol), and the reaction mixture was stirred for 12 h. The reaction mixture was diluted with water, and the aqueous layer was extracted with CH2C12 (3 x 150 mL). The combined organics were washed with brine, dried (MGS04), filtered, and concentrated under reduced pressure to provide 3- (tert-butyldimethylsilyloxymethyl)-benzonitrile (9.1 g, 99%) as a clear oil :H NMR (300 MHz, CDC13) 8 7.51 (s, 1H), 7.42 (d, J = 6 Hz, 1H), 7.35-7. 28 (m, 1H), 4.75 (s, 2H), 0.94 (s, 9H), 0.11 (s, 6H).
The synthetic route of 874-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA CORPORATION; WO2005/18557; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts