Electric Literature of 654-70-6,Some common heterocyclic compound, 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
20L three-necked flask by adding 5.94L water, 270mL thiophosgene, the temperature control in the 20 ~ 30C ,457 g of 4-amino-2- (trifluoromethyl) benzonitrile was added portionwise under stirring,After the addition, the reaction was continued for 1 h. The reaction was complete by TLC method, extracted with dichloromethane (1 L x 3)The organic phases were combined, dried over anhydrous sodium sulfate, filtered, concentrated, added with petroleum ether beating,Through liquid nitrogen crystallization, filtration, drying, the product 500g, yield 89.3%.
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai DingYa Pharmaceutical Chemicals Co.,Ltd; Ruan, Shiwen; Yan, Haiyan; Xia, Hongfei; Xu, LiPing; (6 pag.)CN104016924; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts