Adding a certain compound to certain chemical reactions, such as: 555-21-5, name is 4-Nitrophenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 555-21-5, Formula: C8H6N2O2
A mixture of (4-nitrorhohenyl)-acetonitrile (4.33 g5 27 mmol), NaOH (3.24 g, 81 mmol), iodomethane (5.5 mL, 88 mmol), and tetrabutylammonium iodide (0.56 g, 1.5 mmol) was stirred in water (35 mL) and dichloromethane (35 mL) for 24 hrs at about 25C, extracted with dichloromethane, dried (MgSO4), and concentrated. The residue was dissolved in diethyl ether, filtered through Celite, concentrated, re-filtered through Celite with dichloromethane, and concentrated. This product was dissolved in ethyl acetate, treated with SnCl2 (20 g, 106 mmol). The mixture was stirred overnight at 7O0C, concentrated, and partitioned between ethyl acetate and IN aqueous NaOH. The organic layer was isolated, EPO
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitrophenylacetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; WO2006/65646; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts