Application of 3759-28-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3759-28-2 name is 2-(Cyanomethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of each of 1 (2.38 g, 0.01 mol) and appropriate nitriles 2a-d (0.01 mol) in the presence ofammonium acetate (1.54 g, 0.02 mol) was heated in an oil-bath at 150 oC for 45 min. The reaction mixturewas poured onto ice/HCl. The solid that separated out was filtered, dried and recrystallized fromEtOH-DMF to give compounds 3a-d.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Cyanomethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Fadda, Ahmed A.; Mohamed, Khaled S.; Refat, Hala M.; El-Bialy, Engy E.; Heterocycles; vol. 91; 1; (2015); p. 134 – 148;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts