Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Methyl-3-nitrobenzonitrile
A mixture of 3-nitro-p-tolunitrile (1.2 g; 7.40 mmol), N-bromosuccinimide (2.6 g;14.80 mmol) and benzoyl peroxide (182 mg; 0.75 mmol) in acetic acid (15 mL) in asealed tube was heated at 140C using one single mode microwave (Biotage InitiatorEXP 60) with a power output ranging from 0 to 400 W for 40 mm. The mixture waspoured into ice-water, K2C03 solid and EtOAc were added. The mixture was extracted with EtOAc (3x). The organic layer was dried over MgSO4, filtered and the solvent was evaporated. The residue was taken up with toluene and the solvent was evaporated to give 1.47 g of brown oil of a mixture of intermediate 578 and 3-nitro-p-tolunitrilewhich was used in the next reaction step without any further purification.
According to the analysis of related databases, 939-79-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; PONCELET, Virginie Sophie; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (477 pag.)WO2017/125530; (2017); A1;,
Nitrile – Wikipedia,
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