Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, A new synthetic method of this compound is introduced below., name: 4-Cyano-3-trifluoromethylaniline
General procedure: A substituted aniline (5.0 mmol) and triethylamine (1.87 g,18.5 mmol) were dissolved by dichloromethane (10 mL),and stirred under an ice-water bath, to which chloroacetylchloride (1.29 g, 11.5 mmol) was added dropwise. Afteraddition, the reaction mixture was stirred for one more hourat room temperature, then EA (30 mL) and H2O (30 mL)were added for an extraction. The organic contract waswashed with water (15 mL × 3) and saturated brine (15 mL),dried over Na2SO4 and evaporated under reduced pressureto afford intermediate 5.
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dong, Junze; Zhang, Jingya; Li, Zilu; Asnake, Solomon; Zhang, Daoguang; Olsson, Per-Erik; Zhao, Guisen; Medicinal Chemistry Research; vol. 28; 3; (2019); p. 380 – 386;,
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