Some common heterocyclic compound, 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Methyl-3-nitrobenzonitrile
(b) 3-Amino-4-methylbenzonitrile 120 g of 3-Nitro-4-methylbenzonitrile were suspended in 1.2 l of EtOH and hydrogenated in the presence of 7 g of Pd/C (10%) with 50 l of hydrogen at room temperature. After removal of the catalyst, the solvent was stripped off. 95 g of pure product were obtained (97%). 1 H-NMR (DMSO-d6; delta in ppm): 7.1 (dd, 1H); 6.90 (d, 1H); 6.85 (dd, 1H); 5.35 (s, 2H, NH2 [sic]); 2.15 (s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 939-79-7, its application will become more common.
Reference:
Patent; BASF Aktiengesellschaft; US5932567; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts