Reference of 1187-42-4,Some common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Weigh 97 mg (0.9 mmol)Diaminamethylene nitrile and247 mg (0.7 mmol)The compound 2 obtained in Example 1 was dissolved in 20 mL of ethanol,After adding 5 drops of acetic acid, the mixture was stirred at room temperature for 2 h. The crude product was recrystallized from ethanol,And purified by column chromatography (eluent: petroleum ether / dichloromethane = 2: 1)The resulting product was finally 250 mg in a yield of 82.1percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diaminomaleonitrile, its application will become more common.
Reference:
Patent; Jiangsu University; Gu Lei; Wu Jiacong; Xia Jinchen; Li Yuanyuan; Han Juan; Wang Yun; Ni Liang; (15 pag.)CN106518900; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts