Synthetic Route of 60899-34-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 60899-34-5 as follows.
In a 25 mL single-necked flask, 2,3-dihydro-1-oxo-1H-indene-4-carbonitrile (1.57 g), tetraisopropyl titanate (2.74 g), and S-phenylethylamine (1.45 g), toluene (15 mL), and stirred with heating to 100 C; After the reaction was completed, the temperature of the system was lowered to below 35 C, and an aqueous solution (20 mL) of sodium hydroxide (0.48 g) was added, and the filtrate was collected by stirring and filtration. The filtrate was concentrated to obtain 2.3 g of (S,Z)-1-((1-phenylethyl)imino)-2,3-dihydro-1H-indene-4-carbonitrile with a yield of 87.8% and a purity of 95.0%.
According to the analysis of related databases, 60899-34-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Xu Guobin; Sun Guodong; Wang Zhongqing; Hu Yanqing; Su Wei; Luo Zhonghua; Huang Fangfang; (9 pag.)CN110615747; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts