Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20249-16-5, name is 3-Oxocyclobutanecarbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Oxocyclobutanecarbonitrile
Compound 10-2 (8.0g, 84.21mmol) was dissolved in DCM (80mL) at 0C, added DAST (27g, 0.168mol). The reaction mixture was stirred overnight at room temperature, and the end of the reaction was monitored by TLC (petroleum ether/ethyl acetate = 3: 1). Ice water was added to the reaction solution, extracted with DCM, washed with saturated brine, and then dried over anhydrous Na2SO4. The organic layer was concentrated under reduced pressure and purified by column chromatography (petroleum ether/ethyl acetate = 150: 1-30:1) to give the crude Compound 10-3 (8.1g) as a brown oil.
The synthetic route of 20249-16-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KBP Biosciences Co., Ltd.; ZHANG, Hui; DONG, Yanyan; EP2738156; (2014); A1;,
Nitrile – Wikipedia,
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