Some common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C12H6N2O
As shown in the above reaction formula,The compound of the formula (2-9-1) obtained in the above Preparation Example 2 (157.4 mg,0.1mmol),a compound of the formula (a-2-1) (78 mg, 0.4 mmol; purchased from TCI),Pyridine (0.8 mL, 0.96 mmol)Add chloroform (30 mL) to the reaction vessel and pass argon for 25 min.It was then refluxed at 65 C for 15 h.After cooling to room temperature (about 25 C), the reaction product was poured into 200 mL of methanol and filtered, and the resulting precipitate was chromatographed on silica gel (using 200-300 mesh).Separation of silica gel with eluent in a volume ratio of 1:2 petroleum ether/dichloromethane to give a blue solid(173.6 mg, yield 90.1%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1080-74-6, its application will become more common.
Reference:
Patent; Peking University; Zhan Xiaowei; Wang Jiayu; (33 pag.)CN108794504; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts