Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-(3-Fluorophenyl)acetonitrile
(0086) In a charge of 200 ml of methanol, 25.9 g (=0.1 mol) of aldehyde of the formula (II), where R1=-COOCH3, R4=-CH3 and R5 and R6=-CH3, and 13.5 g (=0.1 mol) of 3-fluorophenylacetonitrile were introduced. Subsequently, the pH was adjusted to around 10 with ca. 1 g of a 50% aqueous potassium hydroxide solution and the reactor contents were heated to a temperature of 60 C. and then stirred for ca. 6 hours. The mixture was then cooled to 25 C. and the reaction product isolated on a Nutsche filter. The filter cake was washed with ca. 50 ml of methanol and ca. 500 ml of water (T=90 C.). The washed product was dried in a vacuum drying cabinet at a temperature of 80 C. and a pressure of 200 mbar. (0087) Yield: 24.5 g (corresponds to 65% of theory), melting point 311 C.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LANXESS Deutschland GmbH; BORST, Hans-Ulrich; LINKE, Frank; MICHAELIS, Stefan; (10 pag.)US2017/349752; (2017); A1;,
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