Related Products of 15666-97-4,Some common heterocyclic compound, 15666-97-4, name is Octyl 2-cyanoacetate, molecular formula is C11H19NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 500 mL three-neck flask reactor equipped with a thermometer,32 mL (0.25 mol) of n-octyl cyanoacetate was added,Tetrabutyl ammonium bromide 10mL,3-Diethylamino acrolein62mL (0.5mol),Place the prepared device in the microwave.Set microwave radiation conditions, 40C temperature,Microwave power is 100W and frequency is 2450MHz.TLC test (petroleum ether:dichloromethane 1:2 development, sublimation iodine coloration) 3-diethylamino acrolein reaction is complete,Cool down to room temperatureHCl gas was passed through and the reaction was continued under microwave irradiation and the reaction was followed by HPLC until the reaction was complete.Add 5% potassium hydroxide solution to adjust the pH = 5-6, liquid separation, the aqueous layer was extracted with butyl acetate 20mL × 3 times,The organic layers are combined, washed after washing, and the molecular sieves are dried.After filtration and evaporation of the solvent, butyl acetate is recovered.An n-octyl 2-chloronicotinate was obtained, 61.3 g of a colorless liquid, with a yield of 92.4%. :
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Octyl 2-cyanoacetate, its application will become more common.
Reference:
Patent; Shandong Normal University; Liu Yufa; Li Dechao; Gu Qiaolian; Sun Lin; Xu Jun; Zhao Jianxia; Cheng Guiying; (11 pag.)CN104945316; (2018); B;,
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