In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22364-68-7, name is 2-(o-Tolyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 22364-68-7
General procedure: Nitriles (1 mmol) were added to a solution of NaN3 (3 mmol), PhMe (50 mL), and Et3N.HCl (3 mmol) in around-bottomed flask. The reaction mixture was stirred at 110 C. After completion of the reaction (as indicated byTLC), the product was cooled and extracted with water. Next, 36% HCl was added dropwise to the aqueous layer to precipitate the tetrazoles. After filtration, the solid wasdried under reduced pressure and recrystallized fromEtOAc/Et2O to yield the 5-substituted-1-H-tetrazoles.
The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liao, Ai-Mei; Wang, Tiantian; Cai, Bangrong; Jin, Yi; Cheon, Seunghoon; Chun, Chang Ju; Wang, Zengtao; Archives of Pharmacal Research; vol. 40; 4; (2017); p. 435 – 443;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts