Adding a certain compound to certain chemical reactions, such as: 53312-80-4, name is 4-Amino-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53312-80-4, category: nitriles-buliding-blocks
Water (10 mL) was added to a single-necked flask, and then thiophosgene (1.27g) was added dropwise. After stirring at 25 C for 0.5 h under nitrogen protection, Compound 59-1 (1.00 g) was added in batches, and the resulting mixture further reacted at 25 C for 2 h. The reaction mixture was extracted with dichloromethane (10 mL×3). The organic phase was washed with saturated brine (15 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated. The residue obtained from the concentration was purified by column chromatography to obtain Compound 59-2. 1H NMR (400 MHz, CDCl3) delta ppm 7.63(dd, J=8.38, 7.06Hz, 1H), 7.10-7.15 (m, 1H), 7.07 (dd, J=9.15, 1.87Hz, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; SHEN, Chunli; WU, Chengde; CHEN, Shenglin; CHEN, Shuhui; ZHANG, Xiquan; TIAN, Xin; (200 pag.)EP3666772; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts