These common heterocyclic compound, 876-31-3, name is 4-(Cyanomethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H6N2
a) 4-Cyanophenylacetic acid 1 g (7.03 mMol) of 4-cyanophenylacetonitrile was added to conc. hydrochloric acid preheated to 105C and kept at this temperature for 5 minutes. It was cooled to 0C, the precipitate formed was collected and washed thoroughly with ice water. After purification by column chromatography on silica gel (Macherey-Nagel, 35-70 mesh ASTM) using ethyl acetate/methanol/glacial acetic acid = 95/5/0.5 (v/v/v) as eluant, 0.5 g (44% of theory) of colourless crystals were obtained Mp. 152.154C. IR (KBr): 2229.6 (C N), 1697.2 (Carboxylic acid-C=O) cm-1
The synthetic route of 4-(Cyanomethyl)benzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dr. Karl Thomae GmbH; EP885186; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts