Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-(4-Bromophenyl)-3-oxopropanenitrile
General procedure: A dry 50 mL round flask equipped with a magnetic stirring bar was charged with a solution of 3-oxo-3-phenylpropanenitrile (0.87 g, 6.0 mmol), benzaldehyde (0.61 mL, 6.0 mmol), piperidine (0.12 mL, 0.2 equiv), and acetic acid (0.069 mL, 0.2 equiv) in toluene (20 mL). The mixture was heated at 60 C for 12 h. After cooling to room temperature, the mixture was washed with water (10 mL) and the aqueous phase was extracted with ethyl acetate (3×10 mL). The crude mixture was subjected to column chromatography (PE/EA 98:2) to yield 0.68 g (2.9 mmol, 48%) of the desired product as a white solid.
According to the analysis of related databases, 4592-94-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Liu, Wen; Zhou, Jing; Zheng, Changwu; Chen, Xingkuan; Xiao, Hua; Yang, Yingquan; Guo, Yinlong; Zhao, Gang; Tetrahedron; vol. 67; 10; (2011); p. 1768 – 1773;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts